Table 6.
Time and dose dependent histopathological alterations in the liver, kidney and lung (n = 6/group).
| Number of Animals Showing the Respected Alteration in the Respective Group (n = 6/Group) | Total Score (Representing the Severity of the Alteration) 1 | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group (ppm) | 0 (control) | 20 | 50 | 100 | 0 (control) | 20 | 50 | 100 | ||||||||
| length of exposure (day) | 5 | 10 | 5 | 10 | 5 | 10 | 5 | 10 | 5 | 10 | 5 | 10 | 5 | 10 | 5 | 10 |
| Liver | ||||||||||||||||
| Vacuolar degeneration | 0 | 0 | 6 | 6 | 6 | 6 | 6 | 6 | 0 | 0 | 6 | 12 | 9 | 14 | 13 | 16 |
| Cytoplasma fragmentation | 0 | 0 | 4 | 6 | 6 | 6 | 6 | 6 | 0 | 0 | 4 | 6 | 8 | 14 | 12 | 18 |
| Solitaire necrosis (Councilman bodies) | 0 | 0 | 2 | 3 | 4 | 6 | 6 | 6 | 0 | 0 | 2 | 3 | 4 | 12 | 10 | 18 |
| MPS cell proliferation | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 4 | 30 | 12 |
| Kidney | ||||||||||||||||
| Tubular degeneration | 0 | 0 | 4 | 6 | 5 | 6 | 6 | 6 | 0 | 0 | 4 | 10 | 6 | 13 | 12 | 17 |
| Tubular necrosis | 0 | 0 | 0 | 0 | 0 | 6 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 8 | 1 | 12 |
| Detachment of tubular epithelial cells | 0 | 0 | 0 | 0 | 2 | 6 | 6 | 6 | 0 | 0 | 0 | 0 | 2 | 6 | 6 | 12 |
| Tubular dilatation | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 15 |
| Hyaline accumulation | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11 |
| Lung | ||||||||||||||||
| Any alteration | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1 total score has been calculated as the sum of the individual scores (n = 6).