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Raman imaging of resected invasive ductal carcinoma specimen from a 55-year-old patient. (a) Digital photo of excised tissue after NPs administration; (b) Raman imaging of tissue sample; (c) quantitative ratiometric analysis of specific CD47 SERS NP binding to non-specific Isotype IgG SERS NP binding on the human tissue sample. Scale bar represents the specific/non-specific binding ratio of our targeted/isotype-labeled nanoparticles.
