Current burden of climate-sensitive health outcomes	Are temperature and precipitation associated with the health outcome(s) or with the transmission cycle(s) of interest in the area of interest? How important are the associations to the current burdens of climate-sensitive health outcomes? Is there evidence that infectious diseases have already changed their geographic range or seasonality of transmission? Do the number of cases of health outcomes of interest increase or decrease during heatwaves, floods, droughts, and/or storm surges, or have these events affected the transmission cycle? How important is the change? Are there trends for the hazards, suggesting how climate change could affect the burden of climate-sensitive health outcomes over the shorter term? Which populations and regions are particularly vulnerable?
Future burden of climate-sensitive health risks	How much might increasing temperatures and changing precipitation patterns affect the magnitude and pattern of future burdens of the health outcome(s) of interest? How important could this change be over the next few decades? Could climate change alter the geographic range, seasonality, or intensity of transmission of Lyme disease, dengue, and other infectious and re-emerging diseases? Over what time period? How could changes in the patterns of extreme events (heatwaves, droughts, floods, extreme storms) affect the burden of climate-sensitive health outcomes? Over what time period? Based on projections, are health outcomes likely to become more or less sensitive to climate change over time? Could climate change facilitate the emergence of health outcomes that may need more attention? How could hotspots of health outcomes change with climate change?
Environmental factors that could affect population health, including Availability of safe water (quality and quantity) Food security Wildfires Coastal erosion Saltwater intrusion	To what extent do temperature, precipitation, other weather variables, and sea level rise affect access to environmental services? How important is the association? How could water supply and sanitation systems be affected by changes in precipitation or salinization? How could wildfires and coastal erosion, for example, affect access to environmental services or electricity networks? To what extent could changes in these environmental factors affect population vulnerability to the risks associated with climate change?
Social and economic context, including Community services Livelihoods Social capital Economic resources Infrastructure	To what extent do temperature, precipitation, other weather variables, and sea level rise affect social and economic factors? How important is the association? How could climate change affect the future availability and level of community services? Over what time period? To what extent could changes in these socioeconomic factors affect population vulnerability to the other risks associated with climate change? Over what time period?
Health systems, including factors such as Ability to deliver services Access to healthcare facilities Supply chains, particularly during extreme weather and climate events	To what extent do temperature, precipitation, other weather variables, and sea level rise affect the ability of health systems to deliver services? Have extreme weather and climate events affected access to healthcare systems? How important was the disruption? Have extreme weather and climate events affected supply chains? How important was the disruption? Are mechanisms in place to mobilize resources (financial and human) during and after extreme weather and climate events?
Geography and climate	Which regions could be affected by the climate-related hazard? Over what time period? Where are the most vulnerable populations for the health outcome(s) of interest located? Which ecosystems and other services are of importance? Over what time period? Are there other factors of concern?