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. 2018 Oct 17;37(22):4224–4241. doi: 10.1021/acs.organomet.8b00539

Table 5. Ligand Screening: 1-Substituted 1,2,3-Triazole-Containing Phosphine Ligand Mediate, Palladium-Catalyzed, Reaction of Arylchloride 37 in Formation of 32.

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entry ligand conversion [%]a,b
1 29g 49
2 29m 37
3 S-Phos (7) 55
4 X-Phos (8) 5
a

Reaction conditions: 2-chloro-m-xylene (0.5 mmol), 2,4,6-trimethylphenylboronic acid (1.0 mmol), potassium phosphate (2 mmol), Pd2(dba)3 (2.0 mol %), ligand (8.0 mol %), toluene (3 mL), 18 h, reflux.

b

Determined by GC analysis with n-dodecane as internal standard.