Figure 4.

Metabolic flexibility of female mice after eight weeks of HFD feeding (PW 14). (A) RER evolution one hour before refeeding until seven hours upon ad libitum refeeding with a high carbohydrate diet (HDD). Statistical comparison was performed on all of the data points from the moment of food restriction (additional data points not shown to enhance visualization). (B) Mean peak RER values achieved within seven hours after refeeding. (C) Cumulative carbohydrate intake calculated from the automatic records of food intake after access to the refeeding diet. n = 13 for HDD and n = 11 for LDD. Data shown as mean ± s.d. Statistical difference denoted as * p ≤ 0.05.