Table 1.
ISGylated proteins predicted to locate to mitochondria. Proteins identified as ISGylation targets in different proteomic studies [60,68,69,70] predicted to locate to mitochondria. Proteins are grouped according to biological functions.
| Biological Function | Potentially ISGylated Mitocondrial Proteins |
|---|---|
| Host-virus interaction | Acyl-CoA thioesterase 8 (ACOT8) [60] |
| Complement C1q binding protein (C1QBP) [69] | |
| Receptor for activated C kinase 1 (RACK1) [60] | |
| Solute carrier family 25 member 5 (SLC25A5) [69] | |
| Solute carrier family 25 member 6 (SLC25A6) [69] | |
| Staphylococcal nuclease and tudor domain containing 1 (SND1) [69] | |
| Negative regulation of apoptotic process | NME/NM23 nucleoside diphosphate kinase 2 (NME2) [69] |
| Annexin A1 (ANXA1) [69,70] | |
| Glutathione S-transferase pi 1 (GSTP1) [60] | |
| Heat shock protein family A (Hsp70) member 5 (HSPA5) [69] | |
| Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) [60] | |
| Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | Stratifin (SFN) [69] |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta (YWHAB) [69] | |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein épsilon (YWHAE) [69] | |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG) [69] | |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta (YWHAQ) [69] | |
| Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) [69] | |
| ATP biosynthetic process | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle (ATP5A1) [60,69] |
| ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (ATP5B) [60,69] | |
| ATP synthase, H+ transporting, mitochondrial Fo complex subunit G (ATP5L) [70] | |
| Oxidation-reduction process | Aldehyde dehydrogenase 18 family member A1 (ALDH18A1) [70] |
| Fatty acid synthase (FASN) [60,69] | |
| Glutathione-disulfide reductase (GSR) [69] | |
| Lactate dehydrogenase B (LDHB) [69] | |
| Malic enzyme 1 (ME1) [68] | |
| Peroxiredoxin 1 (PRDX1) [60,69,70] | |
| Peroxiredoxin 4 (PRDX4) [69] | |
| Sorbitol dehydrogenase (SORD) [68] | |
| Superoxide dismutase 1, soluble(SOD1) [69] | |
| Thioredoxin reductase 1 (TXNRD1) [60,69] | |
| Thioredoxin (TXN) [69] | |
| Aminoacyl-tRNA synthetase | Alanyl-tRNA synthetase (AARS) [68] |
| Glycyl-tRNA synthetase (GARS) [68] | |
| Phenylalanyl-tRNA synthetase 2, mitocondrial (FARS2) [60] | |
| Tricarboxylic acid cycle | Malate dehydrogenase 1 (MDH1) [69] |
| Malate dehydrogenase 2 (MDH2) [69] | |
| Glycolisis | Oxoglutarate dehydrogenase (OGDH) [60] |
| Pyruvate kinase, muscle (PKM) [60,69,70] | |
| Chaperone | Chaperonin containing TCP1 subunit 7 (CCT7) [69] |
| Heat shock protein 90 alpha family class B member 1 (HSP90AB1) [60,69,70] | |
| Heat shock protein family A (Hsp70) member 1A (HSPA1A) [60,69] | |
| Heat shock protein family D (Hsp60) member 1 (HSPD1) [60,69] | |
| Ion channel | Chloride intracellular channel 1 (CLIC1) [60,69] |
| Annexin A6 (ANXA6) [69] | |
| Other functions | Creatine kinase, mitochondrial 1B (CKMT1B) [69] |
| Ubiquitin-like modifier activating enzyme 1 (UBA1) [69] | |
| Leucine aminopeptidase 3 (LAP3) [60] | |
| 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) [60,69] | |
| clathrin heavy chain (CLTC) [60,69] | |
| Queuine tRNA-ribosyltransferase accessory subunit 2 (QTRT2) [60] | |
| Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase (EHHADH) [69] | |
| ATP binding cassette subfamily F member 2 (ABCF2) [60] |