Table 2.

List of differentially expressed proteins in MKN28 cells treated with PEC, identified using MALDI-TOF/TOF-MS analysis.

No.	Spot No.	Accession No.	Protein Name	MOWSE Score	Sequence Coverage (%)/Peptides Matched	Theoretical Mr (Da)	Theoretical pI Value	Fold Change	Up/Down	p-Value (Anova)
1	774	Q96G01	Protein bicaudal D homolog 1	3.68 × 106	15.4/16	110,751	5.6	2.1	↑	0.002
2	2101	P78344	Eukaryotic translation initiation factor 4 gamma 2	1.50 × 106	12.2/13	102,363	6.7	2.9	↓	0.002
3	1482	Q13873	Bone morphogenetic protein receptor type-2	1.77 × 106	12.8/11	115,202	5.8	2.5	↓	0.002
4	1027	Q8TCG1	Protein CIP2A	2.92 × 106	15.5/13	102,186	5.9	1.5	↓	0.002
5	765	Q68E01	Integrator complex subunit 3	7.80 × 106	16/13	118,071	5.5	7.3	↑	0.003
6	1238	Q92974	Rho guanine nucleotide exchange factor 2	1.39 × 106	15.1/13	111,544	6.9	2.1	↓	0.003
7	1828	P83436	Conserved oligomeric Golgi complex subunit 7	1.84 × 106	15.7/8	86,345	5.3	3.9	↓	0.004
8	1881	P42566	Epidermal growth factor receptor substrate 15	2.84 × 1010	23.4/19	98,657	4.5	2.7	↓	0.004
9	2049	O95235	Kinesin-like protein KIF20A	7.75 × 106	16.2/12	100,279	6.5	2.3	↓	0.005
10	1250	Q13127	RE1-silencing transcription factor	1.88 × 106	16.8/19	121,873	6.3	2.3	↑	0.005
11	866	Q9Y5B9	FACT complex subunit SPT16	6.78 × 1011	30.6/37	119,915	5.5	1.7	↑	0.007
12	1281	Q86T65	Disheveled-associated activator of morphogenesis 2	1.35 × 107	16.8/21	123,500	6.4	1.5	↓	0.007
13	1477	O75665	Oral-facial-digital syndrome 1 protein	1.49 × 106	15.7/21	116,672	5.8	2.1	↓	0.008
14	650	O43295	SLIT-ROBO Rho GTPase-activating protein 3	2.74 × 109	22.2/26	124,505	6.2	1.8	↑	0.008
15	1558	P42338	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	3.92 × 106	15.7/15	122,763	6.7	2.6	↓	0.008
16	1319	Q9Y5B0	RNA polymerase II subunit A C-terminal domain phosphatase	4.51 × 106	17/13	104,400	5.2	2.4	↓	0.009
17	1431	Q13443	Disintegrin and metalloproteinase domain-containing protein 9	3.67 × 106	17.6/12	90,557	7.7	2.2	↓	0.009
18	1648	Q6UWE0	E3 ubiquitin-protein ligase LRSAM1	1.48 × 106	16.3/14	83,595	5.7	1.5	↓	0.009
19	663	Q9C0C4	Semaphorin-4C	368,935	13.2/8	92,624	6.9	2.7	↑	0.009
20	605	Q8IZS8	Voltage-dependent calcium channel subunit alpha-2/delta-3	1.19 × 106	16.5/15	123,012	5.5	2.6	↓	0.01
21	500	Q8TF21	Ankyrin repeat domain-containing protein 24	1.88 × 106	14/15	124,188	5	2.5	↑	0.01
22	1706	Q9UFE4	Coiled-coil domain-containing protein 39	5.24 × 106	19.4/19	109,901	6.1	2.2	↓	0.011
23	2098	Q8N960	Centrosomal protein of 120 kDa	2.94 × 106	19/19	112,641	5.9	2.3	↓	0.011
24	907	Q8WUM4	Programmed cell death 6-interacting protein	1.07 × 106	15/12	96,024	6.1	1.8	↑	0.012
25	336	Q9H0L4	Cleavage stimulation factor subunit 2 tau variant	7.95 × 106	21.1/18	64,437	6.8	1.6	↓	0.013
26	841	Q9UJV9	Probable ATP-dependent RNA helicase DDX41	1.14 × 106	16.7/15	69,838	6.4	1.9	↑	0.013
27	858	O00291	Huntingtin-interacting protein 1	1.99 × 106	20.3/25	116,222	5.2	3	↑	0.015
28	2170	Q9H0B6	Kinesin light chain 2	6.75 × 106	22.3/13	68,935	6.7	2.3	↓	0.021
29	634	P15498	Proto-oncogene vav	3.27 × 106	16/13	98,315	6.2	2.2	↑	0.023
30	1790	P14735	Insulin-degrading enzyme	8.77 × 1011	22.1/28	117,970	6.2	1.6	↓	0.023
31	751	Q8IXT5	RNA-binding protein 12B	1.05 × 106	16.4/15	118,104	6.3	1.7	↑	0.025
32	1644	O60603	Toll-like receptor 2	1.03 × 106	16.8/13	89,838	6.2	1.8	↓	0.027
33	2044	Q9NQI0	Probable ATP-dependent RNA helicase DDX4	1.06 × 107	18.2/13	79,308	5.6	2.6	↓	0.032
34	831	Q9Y5A7	NEDD8 ultimate buster 1	5.37 × 106	20.7/15	70,539	5.7	2.4	↑	0.035
35	1377	Q8TBZ0	Coiled-coil domain-containing protein 110	1.97 × 106	19.9/21	96,726	5.9	1.6	↓	0.035
36	1562	P57740	Nuclear pore complex protein Nup107	3.63 × 106	18.9/15	106,375	5.3	1.5	↓	0.036
37	1686	O75146	Huntingtin-interacting protein 1-related protein	1.39 × 106	11.1/13	119,389	6.2	2.5	↓	0.038
38	1340	Q6DN90	IQ motif and SEC7 domain-containing protein 1	3.48 × 106	15.7/16	108,315	6.5	2.3	↓	0.042
39	664	Q8IZ41	Ras and EF-hand domain-containing protein	1.35 × 106	18/12	82,880	5	2.3	↑	0.043

↑ higher expression; ↓ lower expression.