Table 2.

Common variants (MAF ≥ 5%) with p < 1 × 10⁻⁸. ^a

Desaturase	Gene	Lead SNP	Chr:Position (b37)	EAF	Effect Allele/ Other Allele	Serum			Adipose Tissue
						Direction	p	n	Direction	p	n
D5D	FADS1	rs174549	11:61571382	0.33	A/G	−	1.9 × 10−70	1448	−	1.1 × 10−27	766
D6D	FADS2	rs138194593	11:61620703	0.63	CTCTT/C	+	3.0 × 10−67	1448	−	7.9 × 10−1	611
D6D	PDXDC1	rs6498540	16:15130594	0.71	A/G	+	4.8 × 10−8	1448	−	2.9 × 10−1	611
D6D	near MC4R	rs9957425	18:57462103	0.61	T/C	+	3.7 × 10−8	1448	−	9.0 × 10−1	611
SCD	PKD2L1	rs603424	10:102075479	0.14	A/G	−	1.6 × 10−4	1453	−	2.2 × 10−19	783

^a A, adenine; C, cytosine; Chr, chromosome; b37, NCBI build 37; D5D, δ-5-desaturase; D6D, δ-6-desaturase; EAF, effect allele frequency; FADS1, fatty acid desaturase 1; FADS2, fatty acid desaturase 2; G, guanine; MC4R, melanocortin 4 receptor; PDXDC1, pyridoxal-dependent decarboxylase domain containing 1; PKD2L1, polycystic kidney disease 2-like 1; SCD, Stearoyl-CoA desaturase; T, thymine.