Table 3.
Associations of significant desaturase loci with BMI and metabolic traits. a
| Gene | rs ID b | Chr:Position (b37) | Effect Allele | EAF | ULSAM + PIVUS Meta-Analysis (n = 1453) | ULSAM (n = 564) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HDL Cholesterol | Triglycerides | BMI | HOMA-IR | M-Value | ||||||||||
| Direction | p | Direction | p | Direction | p | Direction | p | Direction | p | |||||
| FADS1 | rs174549 | 11:61571382 | A | 0.33 | − | 2.0 × 10−2 | + | 1.8 × 10−1 | + | 5.4 × 10−1 | + | 6.9 × 10−1 | − | 7.6 × 10−1 |
| FADS2 | rs968567 | 11:61595564 | T | 0.15 | − | 2.4 × 10−1 | + | 5.5 × 10−1 | + | 1.1 × 10−1 | + | 5.6 × 10−2 | − | 2.1 × 10−1 |
| FADS2 | rs138194593 | 11:61620703 | CTCTT | 0.63 | + | 9.3 × 10−3 | − | 4.2 × 10−1 | − | 1.8 × 10−1 | − | 7.9 × 10−1 | + | 5.3 × 10−1 |
| FADS2 | rs2072113 | 11:61604967 | T | 0.17 | − | 7.6 × 10−2 | + | 3.9 × 10−1 | − | 7.3 × 10−1 | − | 2.5 × 10−1 | + | 5.8 × 10−1 |
| PDXDC1 | rs6498540 | 16:15130594 | A | 0.71 | + | 7.8 × 10−1 | − | 8.5 × 10−1 | − | 4.2 × 10−1 | + | 3.7 × 10−1 | + | 7.6 × 10−1 |
| near MC4R | rs9957425 | 18:57462103 | T | 0.61 | − | 2.2 × 10−1 | + c | 2.1 × 10−3 | + c | 7.4 × 10−4 | + | 7.1 × 10−2 | − c | 3.8 × 10−3 |
| PKD2L1 | rs603424 | 10:102075479 | A | 0.14 | + | 8.4 × 10−1 | + | 5.2 × 10−1 | + | 8.8 × 10−1 | + | 8.8 × 10−1 | − | 7.6 × 10−2 |
a Chr, chromosome; b37, NCBI build 37; EAF, effect allele frequency; FADS1, fatty acid desaturase 1; FADS2, fatty acid desaturase 2; PDXDC1, pyridoxal-dependent decarboxylase domain containing 1; MC4R, melanocortin 4 receptor; PKD2L1, polycystic kidney disease 2-like 1; PIVUS, Prospective Investigation of Uppsala Seniors; ULSAM, Uppsala Longitudinal Study of Adult Men; HDL, high-density lipoprotein; BMI, body mass index; HOMA-IR, homeostasis model assessment of insulin resistance. b Reference SNP ID number. c Significant association after adjustment for multiple testing.