Figure 2.

Role of FTO in the regulation of hepatic gluconeogenesis. FTO regulates hepatic gluconeogenic gene expression by altering the activity of and interaction with transcription factors. Increased FTO expression and/or activity causes an increased transcription of genes encoding gluconeogenic enzymes, leading to an increased gluconeogenesis, while reduced FTO expression and/or activity causes the opposite effect. FTO: Fat mass and obesity-associated, G6PC: Glucose-6-phosphatase, PCK: Phosphoenolpyruvate carboxykinase, STAT3: Signal transducers and activators of transcription 3, CREB: cAMP responsive element binding protein, C/EBP-β: CCAAT/enhancer-binding protein-beta, ATF4: Activating transcription factor 4, FoxO1: Forkhead box protein O1. Red arrow: Stimulation. Blue arrow: Inhibition.