Figure 1.

Schematic representation of the HIV envelope glycoprotein (Env) trimer of dimers (adapted from Tedbury and Freed [1]). The gp120 subunit is in pink and the three domains of the gp41 subunit are represented in pink, yellow, and green. The plasma membrane is indicated in black with the transmembrane domain (TMD) of gp41 spanning the membrane, bridging the extracellular gp120 subunit and the intracellular cytoplasmic tail (CT). The location of the conserved endocytosis motif, Y⁷¹²xxΦ, is indicated with a dashed line. The location of the three lentivirus lytic peptides (LLP) in the CT are indicated along the CT.