Table 2.
Clinical characteristics, treatment and outcome after return of spontaneous circulation.
| Total n = 551 (68%) |
< 75 years n = 426 (68%) |
⩾ 75 years n = 125 (66%) |
p value | |
|---|---|---|---|---|
| Clinical characteristics | ||||
| Glasgow Coma Score at admission* | 4 (3, 13) | 4 (3, 14) | 3 (3, 9) | 0.450 |
| STEMI (%) | 183 (33%) | 157 (39%) | 26 (22%) | <0.001 |
| NSTEMI (%) | 72 (13%) | 51 (12%) | 21 (17%) | 0.160 |
| Wall motion abnormalities (%) | 82 (15%) | 73 (32%) | 9 (21%) | 0.150 |
| LVEF (%) | 0.830 | |||
| Poor–moderate | 62 (24%) | 50 (31%) | 12 (33%) | |
| Reasonable–normal | 133 (65%) | 109 (69%) | 24 (67%) | |
| Laboratory values | ||||
| Glucose* | 12.7 (9.9, 16.9) | 12.3 (9.6, 16.6) | 13.2 (10.6, 17.1) | 0.060 |
| Lactate* | 6.2 (2.95, 9.75) | 6.3 (2.9, 9.9) | 5.4 (3.1, 8.7) | 0.470 |
| pH* | 7.25 (7.10, 7.33) | 7.25 (7.1, 7.32) | 7.27 (7.11, 7.34) | 0.510 |
| Base excess* | −8.1 (−14.5, −3.9) | −8.1 (−14.7, −3.8) | −7.9 (−12.9, −3.95) | 0.640 |
| CK max* | 1943 (436, 5585) | 2390 (607, 6376) | 628 (286, 3104) | <0.001 |
| CK-MB max* | 169 (64, 554) | 214 (77, 587) | 110 (44, 241) | <0.001 |
| Troponin T max* | 2.22 (0.29, 11.33) | 2.53 (0.39, 12.30) | 0.99 (0.20, 6.30) | 0.016 |
| NT-pro BNP* | 313 (75, 1607) | 229 (69, 898) | 1731 (312, 3619) | <0.001 |
| Treatment | ||||
| Coronary angiography (%) | 295 (54%) | 255 (60%) | 40 (32%) | <0.001 |
| Primary | 217 (39%) | 185 (43%) | 32 (26%) | <0.001 |
| Secondary | 78 (14%) | 70 (16%) | 8 (6%) | 0.005 |
| Door to balloon time (min)* | 88 (56, 128) | 88 (55, 125) | 83 (61, 137) | 0.270 |
| Culprit lesion known (%) | 295 (54%) | 255 (60%) | 40 (32%) | 0.089 |
| Right coronary artery | 67 (12%) | 58 (14%) | 9 (7%) | |
| Left anterior descending | 111 (20%) | 97 (23%) | 14 (11%) | |
| Circumflex | 44 (8%) | 37 (9%) | 7 (6%) | |
| Left main | 12 (2%) | 7 (2%) | 5 (4%) | |
| Graft | 4 (1%) | 4 (1%) | 0 (0%) | |
| Unknown or multiple | 32 (6%) | 28 (7%) | 4 (3%) | |
| No culprit | 25 (5%) | 24 (6%) | 1 (1%) | |
| PCI (%) | 215 (39%) | 184 (43%) | 31 (25%) | <0.001 |
| Primary | 191 (35%) | 164 (39%) | 27 (22%) | <0.001 |
| Secondary | 24 (4%) | 20 (5%) | 4 (2%) | 0.470 |
| Intra-aortic balloon pump (%) | 73 (13%) | 60 (14%) | 13 (10%) | 0.290 |
| Mild therapeutic hypothermia (%) | 201 (37%) | 161 (38%) | 40 (32%) | 0.280 |
| Mechanical ventilation (%) | 145 (26%) | 118 (28%) | 27 (22%) | 0.200 |
| Outcome | ||||
| Length of hospital stay (days)* | 6 (3, 18) | 7 (3, 20) | 4 (2,12.5) | <0.001 |
| In-hospital death (%) | 268 (49%) | 184 (43%) | 84 (67%) | <0.001 |
| Neurological bad outcome | 184 (33%) | 132 (31%) | 52 (42%) | |
| Cardiogenic shock | 43 (8%) | 25 (6%) | 18 (14%) | |
| Multiorgan failure | 17 (3%) | 12 (3%) | 5 (4%) | |
| Other | 24 (4%) | 15 (4%) | 9 (7%) | |
| Hospital survival (%) | 283 (51%) | 242 (57%) | 41 (33%) | <0.001 |
| CPC at discharge (%) | 0.041 | |||
| 1 | 239 (84%) | 209 (86%) | 30 (71%) | |
| 2 | 36 (13%) | 27 (11%) | 9 (21%) | |
| 3 | 9 (3%) | 6 (3%) | 3 (7%) | |
| Survival at end of follow up (%) | 185 (33%) | 178 (42%) | 7 (6%) | <0.001 |
*
Median (interquartile range).
CK-MB, creatine kinase-myocardial band; CPC, cerebral performance category; LVEF, left ventricular ejection fraction; (N)STEMI, (non)-ST-segment elevation myocardial infarction; NT-pro BNP, N-terminal prohormone of brain natriuretic peptide; PCI, percutaneous coronary intervention; ROSC, return of spontaneous circulation.