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Time courses of the changes in glucose, lactate and pyruvate production and oxygen consumption due to glycerol or lactate and glucagon in perfused livers of control (A,C) and cafeteria-fed (B,D) rats. Livers of overnight (12-h) fasted rats were perfused as described in Materials and methods. Glycerol (2 mM) or lactate (2 mM) and glucagon (10 nM) were infused at the times indicated on each graph. Each experimental point is the mean ± standard error of 4–6 experiments.
