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. 2018 Nov 14;10(11):473. doi: 10.3390/toxins10110473

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Homologs of the HigB toxins. (A) The HigB toxin MW1228 showed high conservation in L. ceti, E. faecium, S. pneumoniae, E. coli, P. aeruginosa, and B. cereus. The N-terminal 35 residues (13–48 aa) was the highly conserved region in all of the selected homologues. (B) The toxin MW1928 was the largest protein (106 aa) in the HigBA family and displayed a highly conserved region at N-terminal (10–27 aa) and a less conserved region at C-terminal (95–109 aa). (C) The toxin MW1413 is a small protein (62 aa) in the HigBA family and highly conserved in Staphylococcus species such as S. epidermidius, S. xylosus, S. pseudointermedius, S. saprophyticus, S. warneri, and S. pneumoniae. MW1413 was less conserved in E. faecalis and B. cereus.

Homologs of the HigB toxins. (A) The HigB toxin MW1228 showed high conservation in L. ceti, E. faecium, S. pneumoniae, E. coli, P. aeruginosa, and B. cereus. The N-terminal 35 residues (13–48 aa) was the highly conserved region in all of the selected homologues. (B) The toxin MW1928 was the largest protein (106 aa) in the HigBA family and displayed a highly conserved region at N-terminal (10–27 aa) and a less conserved region at C-terminal (95–109 aa). (C) The toxin MW1413 is a small protein (62 aa) in the HigBA family and highly conserved in Staphylococcus species such as S. epidermidius, S. xylosus, S. pseudointermedius, S. saprophyticus, S. warneri, and S. pneumoniae. MW1413 was less conserved in E. faecalis and B. cereus.