Table 4.
Cox proportional hazards model of overall survival after relapse among stage II (N = 384) and stage III (N = 1012) colon cancer patients who relapsed
| Stage II (N = 384) | Stage III (N = 1012) | |||||
|---|---|---|---|---|---|---|
| Overall SAR Variables | HR | 95%CI | P‐Value | HR | 95% CI | P‐Value |
| R vs L | 1.34 | (1.073‐1.681) | 0.010 | 1.31 | (1.14‐1.50) | 0.0001 |
| Grade 3/4 vs 1/2 | 1.17 | (0.814‐1.675) | 0.399 | ~ * | ~ | ~ * |
| M vs F | 1.11 | (0.898‐1.372) | 0.334 | 0.99 | (0.867‐1.134) | 0.903 |
| Age | 1.02 | (1.011‐1.030) | <.0001 | 1.02 | (1.014‐1.028) | <.0001 |
| LVI + vs ‐ | 1.11 | (0.841‐1.471) | 0.457 | 1.08 | (0.938‐1.246) | 0.281 |
| PNI + vs ‐ | 1.12 | (0.742‐1.691) | 0.589 | 1.11 | (0.919‐1.349) | 0.273 |
| LN Removed <12 vs ≥12 | 1.08 | (0.869‐1.348) | 0.479 | 1.01 | (0.886‐1.162) | 0.836 |
| ECOG status** 0/1 vs 2+ | 1.07 | (0.862‐1.336) | 0.528 | 0.78 | (0.673‐0.901) | 0.0008 |
| AC No vs. Yes | 1.08 | (0.840‐1.388) | 0.548 | 1.27 | (1.065‐1.514) | 0.008 |
*
HR and P‐value were not generated for stratification variables as the proportionality assumption was not satisfied. Abbreviations: variables stratified in the Cox model: “~”; present: “+”; absent: “‐”; adjuvant chemotherapy: AC; confidence interval: CI; female: F; hazard ratio: HR; left: L; lymph node: LN; lymphovascular invasion: LVI; male: M; perineural invasion: PNI; relapse free survival: RFS; right: R; survival after relapse: SAR.
**
At diagnosis of early stage disease.