Table 2.
Multivariate linear regression of serum total testosterone levels and selected anthropometric, inflammation, lipid, glucose, and iron-related biomarkers.
| Parameters | Univariate | Model 1 * | Model 2 # | Model 3 † | ||||
|---|---|---|---|---|---|---|---|---|
| β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | β (95% CI) | p Value | |
| Log Age (years) | −1.463 (−2.201~−0.724) | <0.001 | −1.463 (−2.201~−0.724) | <0.001 | −1.098 (−1.903~−0.293) | 0.008 | −1.159 (−1.876~−0.442) | 0.002 |
| W/H ratio | −9.115 (−12.698~−5.531) | <0.001 | −7.623 (−11.519~−3.727) | <0.001 | −1.610 (−7.150~3.930) | 0.566 | ||
| Log BMI (kg/m2) | −3.789 (−5.057~−2.521) | <0.001 | −3.557 (−4.768~−2.346) | <0.001 | −3.557 (−4.768~−2.346) | <0.001 | −1.426 (−3.104~0.252) | 0.095 |
| Blood Biomarkers | ||||||||
| HOMA-IR | −0.403 (−0.552~−0.253) | <0.001 | −0.366 (−0.511~−0.222) | <0.001 | −0.188 (−0.360~−0.016) | 0.033 | ||
| Fasting glucose (mg/dL) | −0.006 (−0.020~0.007) | 0.366 | ||||||
| Log Insulin (µIU/mL) | −1.204 (−1.614~−0.794) | <0.001 | −1.156 (−1.543~−0.768) | <0.001 | −0.723 (−1.210~−0.235) | 0.004 | −0.713 (−1.259~−0.166) | 0.011 |
| Total cholesterol (mg/dL) | −0.003 (−0.009~0.003) | 0.311 | ||||||
| Log TG (mg/dL) | −0.882 (−1.249~−0.516) | <0.001 | −0.708 (−1.091~−0.324) | <0.001 | −0.345 (−0.732~0.041) | 0.080 | ||
| Log HDL (mg/dL) | 1.908 (0.998~2.817) | <0.001 | 1.736 (0.865~2.607) | <0.001 | 0.789 (−0.130~1.707) | 0.092 | ||
| LDL-C (mg/dL) | −0.006 (−0.013~0.001) | 0.059 | ||||||
| RBC (MIL/mm3) | 0.051 (−0.255~0.357) | 0.741 | ||||||
| Log Hb (gm/dL) | 1.350 (−0.412~3.111) | 0.132 | ||||||
| Free Hb (µg/mL) | −0.002 (−0.007~0.003) | 0.350 | ||||||
| Serum Fe (µg/dL) | 0.004 (−0.002~0.010) | 0.204 | ||||||
| Log Ferritin (ng/mL) | −0.259 (−0.597~0.079) | 0.132 | ||||||
| Log TS (%) | 0.820 (0.227~1.414) | 0.007 | 0.718 (0.151~1.286) | 0.014 | 0.577 (0.066~1.087) | 0.027 | 0.675 (0.076~1.274) | 0.048 |
| sCD163 (ng/mL) | −0.001 (−0.001~−0.000025) | 0.062 | ||||||
| Hepcidin (ng/mL) | −0.002 (−0.005~0.001) | 0.175 | ||||||
| Log RBC Deformability SS1/2 (Pa) | −3.137 (−6.300~0.025) | 0.052 | ||||||
| Log RBC Aggregation CSS (mPa) | −2.447 (−3.483~−1.411) | <0.001 | −2.223 (−3.239~−1.207) | <0.001 | −1.650 (−2.635~−0.665) | 0.001 | −1.025 (−2.043~−0.008) | 0.048 |
* Model 1: adjusted for log-age; # Model 2: adjusted for log-age and log-BMI; † Model 3: adjusted for log-age, log-BMI, log-insulin, log-TS and log-RBC aggregation. Abbreviations are defined in the footnotes to Table 1.