Table 1.
Association of five copy number variants with obesity risk in Mexican children (n = 921).
| Locus | Gene | CN Range | Classification | Normal Weight | Obese | Association | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| n | % | n | % | OR | 95% CI | P-value | ||||
| 11q11 | OR4P4, OR4S2 | 0–8 | Deletion | 199 | 41.0 | 151 | 34.6 | 0.774 | 0.634–0.945 | 0.047 |
| OR4C6 | ≥2 copies | 286 | 59.0 | 285 | 65.4 | |||||
| 1p21.1 | AMY1 | 2–19 | Less 6 copies | 116 | 23.9 | 128 | 29.4 | 1.323 | 0.984–1.780 | 0.064 |
| ≥6 copies | 369 | 76.1 | 308 | 70.6 | ||||||
| 16p12.3 | GPRC5B | 1–4 | Deletion | 11 | 2.3 | 13 | 2.9 | 1.307 | 0.472–3.622 | 0.606 |
| ≥2 copies | 474 | 97.7 | 423 | 97.1 | ||||||
| 1p31.1 | NEGR1 | 1–4 | Deletion | 25 | 5.2 | 23 | 5.3 | 1.078 | 0.425–3.622 | 0.867 |
| ≥2 copies | 460 | 94.8 | 413 | 94.7 | ||||||
| 10q11.22 | NPY4R | 1–4 | Deletion | 21 | 4.3 | 19 | 4.4 | 1.064 | 0.411–2.758 | 0.898 |
| ≥2 copies | 464 | 95.7 | 417 | 95.6 | ||||||
OR, odds ratio; CI, confidence interval; OR4P4, olfactory receptor family 4 subfamily P member 4 gene; OR4S2, olfactory receptor family 4 subfamily S member 2 gene; OR4C6, Olfactory receptor family 4 subfamily C member 6 gene; AMY1, salivary amylase gene; GPRC5B, G protein-coupled receptor class C group 5 member B gene; NEGR1, neuronal growth regulator 1 gene; NPY4R, neuropeptide Y receptor Y4 gene. Associations were tested by logistic regression and adjusted by sex and age.