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. 2018 Nov 2;10(11):1618. doi: 10.3390/nu10111618

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Key polyphenolic anti-oxidant actions in relation to anti-inflammation. Polyphenols scavenge radicals, chelate metal ions, inhibit ROS production and promote ROS detoxification. On the right panel ROS contribution to inflammation. ROS: reactive oxygen species; RNS: reactive nitrogen species; NOX: NADPH oxidase; SOD: superoxide dismutase; GSH-PX: glutathione peroxidase; ERK: extra-cellular signal regulated kinases; PI3K/AkT: phosphatidylinositide 3-kinases/protein kinase B; EGCG: epigallactocatechine gallate.