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. 2018 Oct 27;10(11):1582. doi: 10.3390/nu10111582

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Polygenic risk scoring (weighted) for hypersensitive immune disorders asthma, autism spectrum disorder, atopic eczema, inflammatory bowel disease and allergic rhinitis (Prism 5.01, 2007). C: represents PRS in controls (N = 307), CMA represent PRS in (former) cow’s milk allergic children (N = 22). (A) PRS scoring with (GWAS) cutoff of P_T < 0.001, (B) PRS scoring with (GWAS) cutoff of P_T < 0.005, (C) PRS scoring with (GWAS) cutoff of P_T < 0.01, (D) PRS scoring with (GWAS) cutoff of P_T < 0.05, (E) PRS scoring with (GWAS) cutoff of P_T < 0.1, (F) PRS scoring with (GWAS) cutoff of P_T < 0.5 and (G) PRS scoring with (GWAS) cutoff of P_T < 1. Parametric test (t-test) was performed to test for differences in means of the PRS between former CMA patients and healthy controls. We assumed a P < 0.05 statistically significant.