Table 2.

Odds ratios polygenic risk score (PRS) analyses.

PRS Analysis	Asthma	ASD	AD	IBD	RA
PT < 0.001	1.79 (1.14–2.84), 0.012	1.59 (1.04–2.44), 0.032	0.82 (0.53–1.28), 0.383	0.82 (0.53–1.28), 0.383	0.82 (0.53–1.28), 0.383
PT < 0.005	1.50 (0.98–2.32), 0.065	0.85 (0.55–1.32), 0.481	0.86 (0.56–1.32), 0.483	0.86 (0.56–1.32), 0.483	0.86 (0.56–1.32), 0.483
PT < 0.01	1.85 (1.16–2.94), 0.009	0.83 (0.54–1.28), 0.410	0.94 (0.61–1.45), 0.780	0.94 (0.61–145), 0.780	0.94 (0.61–1.45), 0.780
PT < 0.05	1.73 (1.13–2.27), 0.012	0.73 (0.47–1.13), 0.161	0.89 (0.58–1.37), 0.596	0.89 (0.58–1.37), 0.596	0.89 (0.58–1.37), 0.596
PT < 0.1	1.74 (1.13–2.66), 0.012	0.45 (0.28–0.74), 0.002	0.77 (0.50–1.18), 0.231	0.77 (0.50–1.18), 0.231	0.77 (0.50–1.18), 0.231
PT < 0.5	1.74 (1.13–2.66), 0.011	0.67 (0.43–1.05), 0.078	1.42 (0.91–2.23), 0.124	1.42 (0.91–2.23 ), 0.124	1.42 (0.91–2.23), 0.124
PT < 1	1.73 (1.13–2.65), 0.012	0.67 (0.43–1.04), 0.074	1.17 (0.76–1.81), 0.479	1.17 (0.76–1.81), 0.479	1.17 (0.76–1.81), 0.479

Odds ratio and the corresponding 95% confidence interval (95% CI) and corresponding P-value for all PRS analyses (logistic regression) based on standardized PRS values representing the effect for one standard deviation change in PRS. ASD: autism spectrum disorder; AD: atopic dermatitis; IBD: inflammatory bowel disease; RA: rheumatoid arthritis. P-values < 0.05 were assumed significant, annotated in bold.