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. 2018 Nov 21;10(11):1812. doi: 10.3390/nu10111812

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Association of the Selenoprotein F (SELENOF) gene expression with disease-free survival and overall survival, in colorectal cancer patients. Kaplan-Meier curves showing disease free survival (DFS) overall survival (OS) of 98 colorectal cancer (CRC) patients from the Czech Republic with higher SELENOF gene expression compared to low expression in tumor tissue. Subjects with higher SELENOF expression than median show poorer prognosis with shorter DFS and OS compared to subjects with lower SELENOF expression (50.9 vs. 65.2 months and 62.9 vs. 72.9 months, respectively; P_DFS = 0.01 and P_OS = 0.021). In multivariable Cox regression analyses adjusted by tumor stage, surgical radicality, and chemotherapy this was associated with a Hazards ratio (HR) point estimate of 2.41 for DFS (95% CI: 1.08, 5.41; P = 0.032) and 4.13 (95% CI: 1.10, 15.39; P = 0.035) for OS.