Table 2.
Correlations
| Category | Name | Pearson’s r | p-value |
|---|---|---|---|
| B | SIFT | − 0.493 | 7.87E-19 |
| B | LRT | −0.486 | 2.76E-18 |
| B | MutationAssessor | −0.573 | 5.22E-26 |
| B | FATHMM | −0.054 | 1.85E-01 |
| B | PROVEAN | −0.546 | 1.86E-23 |
| Meta | VEST3 | −0.699 | 1.08E-42 |
| Meta | MetaSVM | 0.285 | 1.00E + 00 |
| Meta | MetaLR | −0.482 | 5.77E-18 |
| Meta | M-CAP | −0.255 | 8.09E-06 |
| ML | POLYPHEN2 HDIV | −0.672 | 1.67E-38 |
| ML | POLYPHEN2 HVAR | −0.648 | 4.53E-35 |
| ML | MutationTaster | −0.499 | 2.42E-19 |
| ML | CADD | −0.595 | 1.78E-28 |
| ML | DANN | −0.388 | 8.51E-12 |
| ML | FATHMM-MKL | −0.434 | 1.35E-14 |
| ML | GenoCanyon | −0.282 | 7.95E-07 |
| n | GERP++ | −0.405 | 9.34E-13 |
| Cons | phyloP7way vertebrate | −0.441 | 4.79E-15 |
| Cons | phyloP20way mammalian | −0.214 | 1.54E-04 |
| Cons | phastCons7way vertebrate | −0.486 | 2.55E-18 |
| Cons | phastCons 20 way mammalian | −0.256 | 7.35E-06 |
| Cons | SiPhy 29way logOdds | −0.389 | 7.65E-12 |
Pearson’s r correlation coefficient between rank scores and residual activities, together with the associated p-value for significance scoring, for all the predictors used by wANNOVAR. Bold text is used for the highest correlations. Categories are B for “biologically based prediction method”, ML for “Machine Learning based prediction method”, Meta for “Meta prediction method” and Cons for “Conservation scoring tool”