Figure 5.

In vivo anti-tumor effect of CD and SMA–CD on 4T1 tumor-bearing Balb/c mice. Mice were treated for ten days with either CD 20 mg/kg and SMA–CD 10 mg/kg and 20 mg/kg. The control group was injected with a physiological saline solution. Tumor growth/size was estimated manually using a caliper. Data are presented as the average tumor volume ± SEM. **** p < 0.0001. After ten days of treatment, the treatment with free CD reduced tumor growth by 28%, while SMA–CD (10 mg/kg) decreased the tumor volume by 61% and SMA–CD (20 mg/kg) abolished tumor growth.