Table 4.
Cytotoxicity activity of methanol, Acetone and Ethyl Acetate of plant extracts
| Centella asiatica | Curtisia dentata | Warburgia salutaris | Control | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cells | Methanol | Ethyl Acetate |
Acetone | water | Methanol | Ethyl Acetate |
Acetone | water | Methanol | Ethyl Acetate |
Acetone | water | Dox |
| MCF-7 | 77.6 ± 0.12 | 49.36 ± 0.04 | 53.65 ± 0.06 | > 100 | 82.6 ± 0.13 | 61.38 ± 0.05 | 43.24 ± 0.01 | 76.7 ± 0.04 | 59.57 ± 1.23 | 44.59 ± 0.70 | 34.15 ± 0.77 | > 100 | 1.26 ± 0.03 |
| CACO-2 | > 100 | > 100 | 81.88 ± 1.35 | > 100 | 78.56 ± 0.31 | 74.71 ± 1.25 | 57.35 ± 0.04 | > 100 | > 100 | 92.23 ± 0.15 | 73.29 ± 0.16 | > 100 | 2.76 ± 0.06 |
| HELA | 78.30 ± 1.60 | 74.75 ± 0.24 | 56. 88 ± 0.72 | 76.3 ± 0.06 | 61. 30 ± 0.33 | 59.49 ± 0.04 | 45.13 ± 0.03 | 98.7 ± 1.25 | 84. 00 ± 1.25 | 71.27 ± 0.09 | 56. 01 ± 0.38 | 77.5 ± 0.11 | 1.43 ± 0.24 |
| A549 | 68.51 ± 0.25 | 63.73 ± 0.16 | 46.49 ± 0.04 | > 100 | 67.35 ± 0.33 | 53.27 ± 0.76 | 41.55 ± 0.04 | > 100 | 52.51 ± 0.24 | 56.72 ± 1.92 | 44.51 ± 1.25 | > 100 | 2.10 ± 0.11 |
IC50 values of the Cytotoxicity of plant extracts on different cancer cell lines MCF-7, CACO-2, HeLa and A549. DOX = Doxorubicin hydrochloride. Data expressed as mean ± standard deviation, n = 3. (P ≤ 0.05)