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. 2018 Nov 30;10:86. doi: 10.1186/s13073-018-0597-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Entinostat inhibits luminal breast cancer through Myc signaling. a 563 upregulated and 565 downregulated genes with false positive rate (FDR) of 0% were hierarchically clustered using 817 TCGA breast cancer samples. We defined “signatures” as any gene set that contained a minimum of 10 genes and a Pearson node correlation greater than 0.5 in TCGA dataset. Using these criteria, we defined six and three signatures in upregulated and downregulated genes, respectively. b The summary of the characteristics of all signatures