Fig. 6.

Clinical impact of Jun copy number loss in human breast cancer datasets. a Log2-based value of Jun copy number across the intrinsic subtypes in 814 TCGA breast cancer patients. Whiskers represent the 5%–95% distribution, boxes represent the interquartile range (25th and 75th percentiles), and the horizontal line in the box represents the median value. Cut-off value of Jun copy number for deletion was − 0.32. ANOVA p value was calculated by comparing Jun copy number values across all subtypes. b Frequencies of samples with Jun deletion in TCGA (n = 814) or METABRIC (n = 1960) according to the intrinsic subtype. c, d Kaplan-Meier plots on breast cancer-specific survival among luminal breast cancer patients in METABRIC. Patients with survival time of > 20 years were excluded. c Whole luminal A and B breast cancer patients (N = 1091). Cox p value = 8.12e−06. d Luminal breast cancer patients who received hormonal therapies (N = 830). Cox p value = 0.033