Table 1.
Untreated (N = 6) | Entinostat-3wks (N = 4) | Entinostat-6wks (N = 4) | Entinostat-resistant (N = 8) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Percent rank | Chr | Gene | Percent rank | Chr | Gene | Percent rank | Chr | Gene | Percent rank | Chr |
MAX | 1 | 12 | JUN | 0.977 | 4 | JUN | 0.997 | 4 | JUN | 0.999 | 4 |
CALM1 | 0.995 | 12 | CDC42 | 0.975 | 4 | CDC42 | 0.994 | 4 | JAK1 | 0.995 | 4 |
HIF1A | 0.990 | 12 | JAK1 | 0.969 | 4 | JAK1 | 0.992 | 4 | CDC42 | 0.990 | 4 |
ACTN1 | 0.986 | 12 | LCK | 0.969 | 4 | LCK | 0.989 | 4 | CDKN2A | 0.989 | 4 |
FOS | 0.981 | 12 | LYN | 0.965 | 4 | LYN | 0.987 | 4 | LCK | 0.987 | 4 |
HSP90AA1 | 0.976 | 12 | MAP3K7 | 0.960 | 4 | MAP3K7 | 0.984 | 4 | TGFBR1 | 0.984 | 4 |
FOXA1 | 0.972 | 12 | ERBB2 | 0.959 | 11 | CDKN2A | 0.982 | 4 | LRP8 | 0.983 | 4 |
ARF6 | 0.967 | 12 | CDKN2A | 0.952 | 4 | ZBTB17 | 0.979 | 4 | ZBTB17 | 0.981 | 4 |
FBLN5 | 0.963 | 12 | TGFBR1 | 0.950 | 4 | TGFBR1 | 0.977 | 4 | TLE1 | 0.980 | 4 |
NCOA1 | 0.958 | 12 | RBBP4 | 0.948 | 4 | RBBP4 | 0.974 | 4 | LYN | 0.980 | 4 |
NFKBIA | 0.953 | 12 | ZBTB17 | 0.944 | 4 | LRP8 | 0.972 | 4 | RBBP4 | 0.979 | 4 |
Chr, mouse chromosome; Entinostat-3wks, Entinostat-6wks, Entinostat-resistant are samples treated with entinostat for 3 weeks, 6 weeks, and until progression, respectively