Table 2.
Allele distribution of OAS1 polymorphisms in the two populations
| SNP | Tibetan population | Han population | ||||||
|---|---|---|---|---|---|---|---|---|
| Cases, n (%) | Controls, n (%) | P # | OR#(95%CI) | Cases, n (%) | Controls, n (%) | P # | OR#(95%CI) | |
| rs2240190(C > A) | ||||||||
| C | 941(76.8) | 954(79.2) | 918(81.0) | 864(80.0) | ||||
| A | 285(23.2) | 250(20.8) | 0.128 | 1.16(0.96–1.41) | 216(19.0) | 216(20.0) | 0.556 | 0.94(0.76–1.16) |
| rs1131454(A > G) | ||||||||
| A | 778(63.5) | 726(60.3) | 704(62.1) | 610(56.5) | ||||
| G | 448(36.5) | 478(39.7) | 0.110 | 0.88(0.74–1.03) | 430(37.9) | 470(43.5) | 0.004* | 0.78(0.66-0.93) |
| rs10774671(A > G) | ||||||||
| A | 1051(85.7) | 984(81.6) | 896(79.0) | 793(73.4) | ||||
| G | 175(14.3) | 222(18.4) | 0.006* | 0.74(0.59-0.92) | 238(21.0) | 287(26.6) | 0.001* | 0.72(0.59-0.87) |
| rs11066453 (A > G) | ||||||||
| A | 1171(95.5) | 1124(93.4) | 984(86.8) | 937(86.8) | ||||
| G | 55(4.5) | 80(6.6) | 0.022 | 0.66(0.47–0.94) | 150(13.2) | 143(13.2) | 0.807 | 1.03(0.81–1.32) |
SNP single nucleotide polymorphism, CI confidence interval, OR odds ratio
#adjusted by sex and age
*Bonferroni correction was performed with p ≤ 0.0125 (0.05/4) considered significant