Table 4.

Common treatment-related adverse events (> 1% of patients overall) of grade 3. No. (%)

	Overall (n = 210)	< 70 years (n = 157)	≥ 70 years (n = 53)
Hematological toxicities
Neutropenia	38 (18.1)	33 (21.0)	5 (9.4)
Thrombocytopenia	13 (6.2)	9 (5.7)	4 (7.5)
Anemia	7 (3.3)	2 (1.3)	5 (9.4)
Febrile neutropenia	4 (1.9)	2 (1.3)	2 (3.8)
Non-hematological toxicities
Fatigue	13 (6.2)	10 (6.4)	3 (5.7)
Vomiting	3 (1.4)	1 (0.6)	2 (3.8)
Colangitis	3 (1.4)	3 (1.9)	–
Neurotoxicity	3 (1.4)	1 (0.6)	2 (3.8)
Peripheral neuropathy	5 (2.4)	3 (1.9)	2 (3.8)
Alopecia	9 (4.3)	6 (3.8)	3 (5.7)