Fig. 6.
Intra-NAc effects of the A2A receptor agonist CGS 21680 (CGS; 1–2.5 ng/side) on cocaine (COC; 10 mg/kg; left panel) or on the cue (CUE; light and tone previously associated with cocaine self-administration) plus the subthreshold dose of cocaine (COC; 2.5 mg/kg; right panel) on the reinstatement of cocaine seeking behaviors in rats. The number of active and inactive lever presses is shown as mean (± SEM). VEH—vehicle, EXT—extinction training last session.**p < 0.01 vs VEH + VEH; ^^^p < 0.001 vs VEH + COC 2.5 + CUE (Newman-Keuls test). N = 7 rats/group