Table 1.
Intra-PFc effects of KW 6002, SCH 58261, and CGS 21680 on cocaine self-administration. The number of lever presses and the mean of cocaine infusions are shown as the mean (± SEM) from 5 to 8 rats/group
| Treatment and dose | Cocaine (mg/kg/infusion) self-administration | Number of active lever presses | Number of inactive lever presses | Number of cocaine infusions |
|---|---|---|---|---|
| KW 6002 0 μg/side | 0.25 | 306 ± 16 | 3 ± 0.69 | 53 ± 2.4 |
| KW 6002 1 μg/side | 0.25 | 312 ± 13 | 9 ± 1.59 | 54 ± 4.3 |
| KW 6002 2.5 μg/side | 0.25 | 287 ± 12 | 5 ± 1.33 | 47 ± 7.1 |
| KW 6002 0 μg/side | 0.5 | 232 ± 34 | 0 ± 0 | 28 ± 4.2 |
| KW 6002 1 μg/side | 0.5 | 225 ± 25 | 10 ± 7.5 | 33 ± 2.8 |
| KW 6002 2.5 μg/side | 0.5 | 237 ± 8.2 | 10 ± 5.3 | 31 ± 1.2 |
| SCH 58261 0 μg/side | 0.25 | 328 ± 59 | 10 ± 5.0 | 53 ± 9.9 |
| SCH 58261 1 μg/side | 0.25 | 306 ± 92 | 9 ± 2.7 | 35 ± 10 |
| SCH 58261 2.5 μg/side | 0.25 | 257 ± 68 | 11 ± 4.9 | 41 ± 11 |
| SCH 58261 0 μg/side | 0.5 | 154 ± 24 | 6 ± 1.8 | 24 ± 2.6 |
| SCH 58261 1 μg/side | 0.5 | 147 ± 12 | 2 ± 0.8 | 25 ± 1.9 |
| SCH 58261 2.5 μg/side | 0.5 | 134 ± 12 | 1 ± 0.5 | 22 ± 1.6 |
| CGS 21680 0 ng/side | 0.25 | 198 ± 12 | 9 ± 3.8 | 33 ± 1.5 |
| CGS 21680 5 ng/side | 0.25 | 196 ± 6.9 | 6 ± 2.4 | 31 ± 1.9 |
| CGS 21680 10 ng/side | 0.25 | 191 ± 2.4 | 8 ± 3.4 | 31 ± 1.5 |
| CGS 21680 0 ng/side | 0.5 | 165 ± 14 | 8 ± 2.9 | 26 ± 0.9 |
| CGS 21680 1 ng/side | 0.5 | 163 ± 14 | 6 ± 3.1 | 27 ± 2.5 |
| CGS 21680 2.5 ng/side | 0.5 | 156 ± 8.2 | 6 ± 1.7 | 26 ± 1.9 |