Table 4.
Macroscopic and microscopic pathology findings in NHPs that succumbed to low-dose filovirus exposure (number exhibiting finding/total number of animals in group that succumbed).
| Pathology Findings | SUDV 7U | SUDV 8U | EBOV 7U | EBOV 8U |
|---|---|---|---|---|
| Macroscopic gross pathology | ||||
| Petechia | 2/3 | 1/1 | 1/1 | 4/4 |
| Spleen pale | 1/3 | 0/1 | 0/1 | 0/4 |
| Liver pale | 1/3 | 0/1 | 1/1 | 2/4 |
| Lymph nodes firm, or dark | 0/3 | 1/1 | 0/1 | 1/4 |
| Testes red/hemorrhage | 1/3 | 1/1 | 0/1 | 2/4 |
| Injection site abnormality | 1/3 | 1/1 | n.d. | n.d. |
| Microscopic histopathology | ||||
| Splenic fibrin deposition | 3/3 | 1/1 | 1/1 | 4/4 |
| Splenic lymphoid depletion | 3/3 | 1/1 | 1/1 | 4/4 |
| Splenic necrosis | 3/3 | 1/1 | 1/1 | 4/4 |
| Splenic hemorrhage | 2/3 | 1/1 | 1/1 | 3/4 |
| Lymphoid depletion in lymph nodes | 3/3 | 0/1 | 1/1 | 3/4 |
| Lymph node necrosis | 3/3 | 1/1 | 1/1 | 4/4 |
| Adrenal gland necrosis | 1/3 | 1/1 | 1/1 | 1/4 |
| Testicular hemorrhage | 1/3 | 1/1 | 1/1 | 3/4 |
| Hepatocellular necrosis | 2/3 | 1/1 | 1/1 | 2/4 |
n.d.—no data available.