Table 1.
Study specifics
| Study | n | Goal | Treatment | Time point | Retrospective/Prospective | Datacollection | References |
|---|---|---|---|---|---|---|---|
| Bae, 2013 | 300 | Investigate signs and symptoms during temozolomide | Chemotherapy | Treatment | R (cohort) | Medical records on CTCAE version 3.0, grade 1–4 | [32] |
| Brada, 2001 | 138 | Investigate efficacy and toxicity of temozolomide in glioblastoma patients | Chemotherapy | Treatment | P (phase II trial) | Medical records on CTCAE, grade 1–4 | [25] |
| Cao, 2012 | 112 | Investigate safety and efficacy during chemoradiation vs. radiation in elderly patients | Chemoradiation, radiation (hyofractioned) chemotherapy | Diagnosis, treatment | R (cohort) | Medical records on CTCAE version 3.0, grade 1–5 | [33] |
| Chen, 2017 | 712 | Investigate mutant IDH1 and seizures in glioma patients | Diagnosis | R (cross-sectional) | Medical records | [39] | |
| Diamond, 2017 | 50 | Investigate prognostic awareness, communication and cognitive function in patients with glioma | All | P | HADS (score 9 or higher) | [26] | |
| Ening, 2015 | 233 | Investigate risk factors for glioma therapy complications at diagnosis | Surgery, chemotherapy, chemoradiation, radiation | Treatment | R (cohort) | Medical records | [53] |
| Iuchi, 2014 | 121 | Investigate incidence epilepsy in glioma patients | Surgery, chemoradiation | Diagnosis, FU** | R (cohort) | Medical records | [40] |
| Jakola, 2012 | 55 | Investigate the association between location, survival, and long-term health in patients with low grade glioma | Surgery, radiation and/or chemotherapy | FU | P | EORTC-BN20 (Likert score 3 and 4) | [27] |
| Kerkhof, 2013 | 291 | Investigate seizure control of valproic acid | Anti-epileptics | Diagnosis, All (diagnosis and FU) | R (cohort) | Medical records* | [41] |
| Kim, 2013 | 406 | Investigate incidence epilepsy in glioma patients | Surgery, chemoradation, chemotherapy, radiation | Diagnosis, All (diagnosis and FU) | R (cohort) | Medical records* | [42] |
| Kocher, 2005 | 81 | Investigate signs and symptoms during chemoradiation | Chemoradiation | Treatment | R (cohort) | Medical records* | [54] |
| Koekkoek, 2014 | 178 | Investigate signs and symptoms at end-of life | Palliative care | End-of-life | R (cross-sectional) | Developed symptom questionnaire, completed by physician’s and proxies after patient died | [23] |
| Liang, 2016 | 184 | Investigate indidence of epilepsy in supratentorial glioblastoma patients | Surgery, chemotherapy, (intra-tumor) radiotherapy | Diagnosis, FU | R (cohort) | Medical records | [43] |
| Malström, 2012 | 291 | Investigate safety and efficacy during chemotherapy vs. radiation in elderly patients | Chemotherapy, (hypofractioned) radiation | Treatment | P (RCT) | WHO grading system for AE grade 2–5; N/V by National Cancer Institute CTC version 2.0 | [28] |
| Mamo, 2017 | 64 | Investigate adverse events in glioblastoma patients with bevacizumab | Targeted therapy | Treatment | R (cohort) | Medical records, CTCAE grade 3 and 4 | [34] |
| Piribauer, 2003 | 103 | Investigate feasibility and toxicity during lomustine therapy in eldery patients | Chemotherapy | Diagnosis | R (cohort) | Medical records | [44] |
| Posti, 2015 | 142 | Investigate presenting symptoms at diagnosis | Diagnosis | R (cohort) | Medical records from emergency rooms, intensive care unit, and different inpatient wards; hospital and imaging referrals, disch letters | [45] | |
| Rasmussen, 2017 | 1930 | Investigate symptoms in glioma patients | Surgery | Diagnosis | P (cohort) | Danish Neuro-oncology Registry | [29] |
| Russo, 2017 | 527 | Investigate prevalence of headache in glioma patients | Diagnosis | R (cross-sectional) | Face to face interviews | [38] | |
| Sagberg, 2013 | 164 | Investigate responsiveness of EQ-5D in glioma patients with surgery | Surgery | Diagnosis | R (cross-sectional) | Medical records | [46] |
| Saito, 2014 | 76 | Investigate signs and symptoms during chemoradiation in eldery patients | Chemoradiation, radiation, chemotherapy | Treatment | R (cohort) | Medical records-CTCAE grade 3 and 4 | [35] |
| Salmaggi, 2005 | 134 | Set up a registry for glioblastoma patients in Lombardia, Italy | Surgery radiation chemotherapy | Diagnosis | R (cohort) | Medical records-reports on signs/symptoms and seizures | [47] |
| Sanai, 2012 | 119 | Investigate surgery associated complications | Surgery | Diagnosis, treatment | R (cohort) | Medical records and telephone interviews | [48] |
| Seekatz, 2017 | 54 | Screening for symptom burden in glioma patients | All | P(cohort) | Revised Edmonton Symptom Assessment System (ESAS-r) Score 4–10 | [30] | |
| Sizoo, 2010 | 58 | Investigate signs and symptoms at end-of life | Palliative care | End-of-life | R (cohort) | Medical records& charts of nurse specialist on telephone interviews about symptoms based on self-developed checklist | [37] |
| Stupp, 2002 | 64 | Investigate toxicity of chemoradation | Chemoradiation plus adjuvant chemotharapy | Treatment | P (cohort) | Medical records - CTCAE version 2.0, grade 3–4 | [31] |
| Thrier, 2015 | 57 | Investigate signs and symptoms at end-of life | Palliative care | End-of-life | R (cohort) | Daily reporting of signs and symptoms by standardized protocol | [55] |
| Valko, 2014 | 65 | Investigate incidence fatigue after surgery in glioma patients | Surgery | Treatment | P (cohort) | Fatigue Severity Scale (FSS score 4–9), Epworth Sleepiness Scale (ESS score 10 or higher), Hospital Anxiety and Depression Scale (HADS score 10 or higher) | [36] |
| Van Breemen, 2009 | 108 | Investigate seizure control of anti-epileptics | Anti-epileptics | Diagnosis, All (diagnosis and FU) | R (cohort) | Medical records | [49] |
| Woo, 2014 | 198 | Investigate risk factors for seizures in glioma patients | Surgery, chemoradiation, chemotherapy | Diagnosis, FU | R (cohort) | Medical records | [50] |
| You, 2012 | 508 | Investigate incidence epilepsy and postoperative seizure control | Surgery | Diagnosis, FU | R (cohort) | Medical records* | [51] |
| Yuile, 2006 | 133 | Investigate signs and symptoms during radiotherapy | Radiation | Diagnosis | R (cohort) | Medical records | [52] |
*Not explicitly mentioned, **FU follow up