Table 3.

Immunohistochemical features of granulysin-positive ENKTL cases with lower level of expression of the other cytotoxic markers

Case	Site	Age	Sex	CD56	Granzyme B	TIA-1	Perforin	cCD3	CD4	CD8
1	Nasal cavity	22	M	Pos	Neg	Neg	Neg	Pos	Neg	Neg
2	Nasopharynx	54	M	Pos	Neg	Neg	Neg	Pos	Neg	Neg
3	BM	51	M	Pos	Neg	Pos	Neg	Pos	Neg	Neg
4	Stomach	74	M	Pos	Neg	Neg	Pos	Pos	Neg	Neg
5	Maxilla	28	M	Pos	Pos	Neg	Neg	Pos	Neg	Neg
6	Duodenum	56	M	Pos	Pos	Neg	Neg	Neg	Neg	Neg
7	Soft palate	23	F	Pos	Pos	Neg	Neg	Pos	Neg	Pos
8	Nasopharynx	37	M	Pos	Neg	Pos	Neg	Pos	Neg	Neg
9	Nasal septum	17	F	Pos	Neg	Pos	Neg	Pos	Neg	Neg
10	Nasal cavity	50	F	Pos	Pos	Neg	Neg	Pos	Neg	Neg
11	Soft palate	35	F	Pos	Pos	Neg	Neg	Pos	Neg	Neg
12	Nasal septum	8	M	Pos	Pos	Neg	Neg	Pos	Neg	Neg
13	Palate	61	F	Pos	Neg	Pos	Neg	Pos	Neg	Pos
14	Skin/breast	40	F	Pos	Pos	Pos	Neg	Pos	Neg	Neg
15	Stomach	24	M	Pos	Pos	Pos	Neg	Neg	Neg	Neg
16	Nasal fossa	51	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
17	Nasal septum	38	F	Pos	Pos	Pos	Neg	Pos	Neg	Neg
18	Nasopharynx	42	F	Pos	Pos	Pos	Neg	Pos	Neg	Neg
19	Skin	48	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
20	Maxilla	60	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
21	Caecum	26	F	Pos	Pos	Neg	Pos	Pos	Neg	Neg
22	Testicle	18	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
23	Testis	51	M	Pos	Neg	Neg	Neg	Pos	Neg	Neg
24	Skin	24	M	Pos	Pos	Neg	Pos	Neg	Neg	Neg
25	Nasal fossa	44	F	Pos	Pos	Pos	Neg	Pos	Neg	Neg
26	Large bowel	80	M	Pos	Neg	Pos	Neg	Pos	Neg	Neg

All cases were granulysin and EBER positive. TCR rearrangement is not available in all cases but not two (n 3 and 24) that are polyclonal

Pos positive, Neg negative, M male, F female, BM bone marrow, cCD3 cytoplasmic CD3