Table 4.

Immunohistochemical features of granulysin-negative ENKTL cases

Case	Site	Age	Sex	CD56	Granzyme B	TIA-1	Perforin	cCD3	CD4	CD8
1	Nasal cavity	41	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
2	Palate	65	F	Pos	Neg	Pos	Neg	Pos	Neg	Neg
3	Palate	47	M	Pos	Pos	Neg	Neg	Pos	Neg	Pos (weak)
4	Nasal fossa	53	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
5	Nasal fossa	58	F	Pos	Neg	Pos	Neg	Pos	Neg	Neg
6	Nasal fossa	54	M	Pos	Pos	Neg	Neg	Pos	Neg	Neg
7	Nasal sinus	45	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
8	Nasal sinus	44	F	Pos	Pos	Pos	Neg	Pos	Neg	Neg
9	Lymph node	51	F	Pos	Pos	Pos	Pos	Pos	Neg	Neg
10	BM	52	M	Pos	Pos	Pos	Pos	Pos	Neg	Neg
11	Palate	35	M	Pos	Neg	Pos	Neg	Pos	Neg	Neg
12	Nasal cavity	42	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
13	Nasal cavity	61	F	Pos	Neg	Pos	Pos	Neg	Neg	Neg
14	Nasal cavity	54	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
15	Oral cavity	63	F	Pos	Pos	Pos	Pos	Pos	Neg	Neg
16	Palate	47	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
17	Palate	52	M	Pos	Pos	Neg	Neg	Pos	Neg	Neg
18	Nasal cavity	48	F	Pos	Pos	Neg	Neg	Pos	Neg	Neg
19	Maxilla	41	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
20	Lymph node	60	M	Pos	Pos	Pos	Neg	Pos	Neg	Neg
21	Nasal cavity	53	M	Pos	Pos	Pos	Pos	Pos	Neg	Neg
22	Nasal fossa	49	F	Pos	Pos	NA	NA	Pos	Neg	Neg
23	Nasal cavity	41	M	Pos	Pos	NA	NA	Pos	Pos (focal)	Neg
24	Nasal cavity	57	F	Pos	Pos	Pos	NA	Pos	Neg	Pos
25	Nasal cavity	54	M	Pos	Pos	Pos	NA	Pos	Neg	Pos

All cases were EBER positive and granulysin negative. TCR rearrangement is not available in all cases but not one (n 11) that is polyclonal

Pos positive, Neg negative, NA not available, M male, F female, BM bone marrow