Table 2.

Multivariable analysis of prognostic factors for overall survival

Factor		Ref. Level	HR	95% CI	P values
Treatment	Chemotherapy	Erlotinib	0.87	0.72 to 1.04	0.137
Age (years)	Continous		1.00	0.99 to 1.01	0.690
Gender	Female	Male	0.73	0.58 to 0.93	0.011
Smoke habits	Former	Current	1.08	0.85 to 1.36	0.643
	Never		0.95	0.68 to 1.34
Histology	Non-squamous	Squamous	0.87	0.69 to 1.11	0.258
Performance status	>0	0	1.74	1.49 to 2.03	<0.001
K-ras*	Mutated	Non-mutated	1.28	0.99 to 1.65	0.066

Analysis is stratified by study.

*Evaluated only in TAILOR and PROSE trials.