Figure 1.

Topical treatment with AAE alters PUFAs metabolome in murine HFs. Schematic cartoon depicting some of the metabolic reactions positively affected by AAE in murine HFs. Green arrowheads indicate reactions stimulated by AAE. Green dots indicate metabolites, whose intracellular concentration resulted increased by AAE. (COX cyclooxygenase; LOX, lipoxygenase; CYP, cytochrome P450; sEH, soluble epoxide hydroxylase; n.e. non enzymatic. The abbreviations of PUFA metabolites as well as their full IUPAC name are shown in Table S1).