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. 2018 Aug 13;150(6):607–629. doi: 10.1007/s00418-018-1706-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Nucleolar proteins in reduction of cancer development. Some nucleolar proteins such as ARF and certain ribosomal proteins (RPs) of small (RPSs) and of large (RPLs) ribosomal subunit can inhibit the activities of factors participating in and regulating ribosome biosynthesis such as i.a. transcription termination factor I (TTF-I), nucleophosmin (NPM), or c-Myc; in addition, NPM alone can inactivate c-Myc. This results in reduced or stopped ribosome production (white arrows) followed by inhibition of cell proliferation