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. 2018 Nov 7;10(11):615. doi: 10.3390/v10110615

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Concentration of cytokines, chemokines and RNA viral load determined on semen of patients ZIKV17 (A) and ZIKV19 (B). The levels of the following cytokines and chemokines were measured in blood and seminal plasma—IL-2, IL-4, IL-6, CXCL8 (IL-8), IL-10, IL-17, IFN-γ, TNF–α, CCL2 (MCP-1), CCL5 (RANTES), CXCL9 (MIG), CXCL10 (IP-10). The results are representative of two distinct experiments performed in duplicate. Values of p less them 0.05 were considered statistically significant (* p < 0.05; ** p < 0.001; *** p < 0.0001—concentration of cytokines/chemokines in ZIKV patients versus control (semen from Zika—uninfected individual), ### p < 0.0001 correlation of concentration of cytokine/chemokines in different days after symptoms onset). IL-2, IL-4, IL17A and TNF–α were not detected in the seminal plasma of both patients. No cytokines or chemokines were detected in serum of both patients—serum results were below the limit of detection of the kit (20 pg/mL for cytokines and 10 pg/mL for chemokines).

Concentration of cytokines, chemokines and RNA viral load determined on semen of patients ZIKV17 (A) and ZIKV19 (B). The levels of the following cytokines and chemokines were measured in blood and seminal plasma—IL-2, IL-4, IL-6, CXCL8 (IL-8), IL-10, IL-17, IFN-γ, TNF–α, CCL2 (MCP-1), CCL5 (RANTES), CXCL9 (MIG), CXCL10 (IP-10). The results are representative of two distinct experiments performed in duplicate. Values of p less them 0.05 were considered statistically significant (* p < 0.05; ** p < 0.001; *** p < 0.0001—concentration of cytokines/chemokines in ZIKV patients versus control (semen from Zika—uninfected individual), ### p < 0.0001 correlation of concentration of cytokine/chemokines in different days after symptoms onset). IL-2, IL-4, IL17A and TNF–α were not detected in the seminal plasma of both patients. No cytokines or chemokines were detected in serum of both patients—serum results were below the limit of detection of the kit (20 pg/mL for cytokines and 10 pg/mL for chemokines).