Table 2.
Biochemical parameters of the population according to APOC3 genotype.
| Genotype a | Triglyceride (mg/dL) b | Total Cholesterol (mg/dL) | HDL Cholesterol (mg/dL) | LDL Cholesterol (mg/dL) | Fasting Glucose (mg/dL) |
|---|---|---|---|---|---|
| T-455C | |||||
| T/T (n = 1445) | 140.9 (139.0, 142.8) c | 187.4 (186.5, 188.3) | 45.3 (45.0, 45.6) | 114.2 (113.4, 115.0) | 82.5 (82.3, 82.7) |
| T/C (n = 2677) | 142.4 (140.9, 143.9) cd | 187.3 (186.6, 188.0) | 45.4 (45.2, 45.6) | 113.9 (113.3, 114.5) | 82.3 (82.1, 82.5) |
| C/C (n = 1117) | 147.5 (145.2, 149.8) d | 187.8 (186.8, 188.8) | 44.9 (44.6, 45.2) | 114.1 (113.1, 115.1) | 82.4 (82.2, 82.6) |
| p value | 0.009 | 0.816 | 0.350 | 0.823 | 0.590 |
| C-482T | |||||
| C/C (n = 1473) | 140.4 (138.4, 142.4) c | 187.3 (186.4, 188.2) | 45.3 (45.0, 45.6) | 114.2 (113.4, 115.0) | 82.5 (82.3, 82.7) |
| C/T (n = 2676) | 142.7 (141.2, 144.2) cd | 187.5 (186.8, 188.2) | 45.4 (45.2, 45.6) | 113.9 (113.3, 114.5) | 82.3 (82.1, 82.5) |
| T/T (n = 1090) | 147.0 (144.7, 149.3) d | 187.6 (186.6, 188.6) | 44.9 (44.6, 45.2) | 114.0 (113.1, 114.9) | 82.3 (82.1, 82.5) |
| p value | 0.011 | 0.797 | 0.329 | 0.897 | 0.569 |
| C1100T | |||||
| T/T (n = 1833) | 147.2 (145.4, 149) d | 187.6 (186.8, 188.4) | 44.9 (44.7, 45.1) | 113.9 (113.2, 114.6) | 82.4 (82.2, 82.6) |
| T/C (n = 2586) | 142.8 (141.3, 144.3) d | 187.3 (186.6, 188.0) | 45.4 (45.2, 45.6) | 113.9 (113.3, 114.5) | 82.3 (82.1, 82.5) |
| C/C (n = 820) | 134.2 (131.8, 136.6) c | 187.2 (186.0, 188.4) | 45.9 (45.5, 46.3) | 114.7 (113.6, 115.8) | 82.4 (82.1, 82.7) |
| p value | <0.001 | 0.744 | 0.014 | 0.620 | 0.884 |
| SstI | |||||
| C/C (n = 2365) | 139.4 (137.9, 140.9) c | 187.2 (186.5, 187.9) | 45.5 (45.3, 45.7) | 114.2 (113.6, 114.8) | 82.3 (82.1, 82.5) |
| C/G (n = 2352) | 143.9 (142.4, 145.4) c | 187.4 (186.7, 188.1) | 45.3 (45.1, 45.5) | 113.9 (113.3, 114.5) | 82.4 (82.2, 82.6) |
| G/G (n = 522) | 155.4 (151.7, 159.1) d | 188.2 (186.7, 189.7) | 44.5 (44.1, 44.9) | 113.8 (112.4, 115.2) | 82.7 (82.3, 83.1) |
| p value | <0.001 | 0.590 | 0.052 | 0.697 | 0.302 |
C, cytosine; G, guanine; HDL cholesterol, high-density-lipoprotein cholesterol; LDL cholesterol, low-density-lipoprotein cholesterol; T, thymine. Data are presented as means with ranges for clinical parameters. Differences in the genotype were determined using Student’s analysis of variance (ANOVA). Significance was tested using generalized linear model. Some variables included missing values. a The genotype of each SNP was presented as common homozygous, heterozygous, and rare homozygous. b Circulation triglyceride was tested after log transformation. c,d The same lower-case letter means non-significant difference among groups.