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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Neuroscience. 2018 Sep 11;391:25–49. doi: 10.1016/j.neuroscience.2018.09.002

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KAR-mediated currents in cultured OB neurons isolated with KAR agonists (SYM 2081 or kainate) and an AMPAR antagonist (GYKI). A) Coapplication of the selective KAR agonist, SYM 2081, and GYKI following pretreatment with GYKI. As GYKI blocked AMPARs, this current was virtually entirely KAR mediated. B) A similar current is evoked by coapplication of kainate (KA) and GYKI after pretreatment with GYKI. C) GYKI completely blocks AMPAR-mediated currents activated by application of AMPA. D) Sequential application of kainate and kainate + GYKI. E) Application of GYKI during a current evoked by application of kainate. GYKI blocked the AMPAR-mediated portion of this current, revealing the relatively small KAR-mediated component of the current.