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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Neuroscience. 2018 Sep 11;391:25–49. doi: 10.1016/j.neuroscience.2018.09.002

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Kainate has biphasic, concentration-dependent effects on EPSCs recorded in neurons in OB slices, suggesting a role for KARs in modulating excitatory transmission in the OB. EPSCs were evoked in neurons in OB slices by ONL stimulation. A) Compared to the control current, application of 50 nM kainate (KA) significantly increased the mean amplitude of the EPSC, with significant recovery of the current following a wash. B) Histogram showing the effect of 50 nM KA and recovery following a wash expressed as a percentage of the control EPSC amplitude (N=4; * P≤ 0.01 compared to control; # P ≤ 0.05 compared to 50 nM KA). C) Application of 500 nM kainate (KA) significantly decreased the mean amplitude of the EPSC, with significant recover of the current following a wash. D) Histogram showing the effect of 500 nM KA and recovery following a wash expressed as a percentage of the control EPSC amplitude (N=6; *P ≤ 0.01 compared to control; #P ≤ 0.05 compared to 500 nM KA). Values are the mean ± SEM.