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. 2018 May 31;18(6):473–482. doi: 10.1007/s40256-018-0280-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Mechanism of action of sacubitril/valsartan [21]. The inhibition of neprilysin works synergistically with the inhibition of angiotensin receptors by valsartan. ANP/BNP atrial natriuretic peptide/brain natriuretic peptide, ARB angiotensin receptor blocker, AT1R angiotensin II type 1 receptor, NEP neprilysin, NPS natriuretic peptide system, RAAS renin–angiotensin aldosterone system.

Adapted with permission from J Am Coll Cardiol 2015;65(10):1029–41. Copyright 2015: American College of Cardiology Foundation