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. 2018 Nov 13;9(89):35875–35890. doi: 10.18632/oncotarget.26251

Figure 3. RNA sequencing of DIAP cells shows up-regulation of genes involved in DNA repair, DNA replication and immune response.

Figure 3

(a) PCA (Principal component analysis) of control vs treated (8n) biological replicates. (b) Gene expression heat map showed that 1,234 genes were up-regulated, and 3,186 genes were down-regulated in all three biologic replicates in treatments vs. controls. (c) Profile plot showed that 404 up-regulated and 605 down-regulated genes follow the same pattern across treatment vs control in all biological replicates. (d) DAVID database search with up-regulated genes identify GO terms associated with DNA repair, DNA replication, immune response along with others. (e) Log2 fold change vs -log10 P-value visualization of genes associated with DNA repairs (red), DNA replication (green) and immune response (blue). All right most (same vertical line) genes were identified only in 8n-cells but not in DMSO control. On the other hand, all left most (same vertical line) genes were identified only in the DMSO control but absent in 8n-cells.