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. 2018 Nov 13;9(89):35875–35890. doi: 10.18632/oncotarget.26251

Figure 4. Anti-apoptosis and cell proliferation in DIAP cells are a mechanism of therapy failure.

Figure 4

Left panel (a, b, c, d & e) represents results from U2932 cells and right panel (f, g, h, i & j) represents results from VAL cells. (a & f). Principal component analysis (PCA) showed concordance among biological replicates and variance between control vs. treatment groups. (b & g). Heat map of protein expression treatment vs control. (c & h). Profile plot protein expression pattern respectively for both cell lines. (d & i). Top 20 enriched GO terms including negative regulation of apoptosis and positive regulation for cell proliferation respectively for U2932 and VAL cell lines. (e & j). Volcano plot shows 8 proteins are significantly up-regulated and 6 proteins are down-regulated in both cell lines. All right most (same vertical line) proteins identified only in 8n-cells but not in DMSO control. On the other hand, all left most (same vertical line) proteins identified only in DMSO control but absent in 8n-cells.