Skip to main content
. 2018 Nov 21;10(11):658. doi: 10.3390/v10110658

Table 3.

Cox proportional analyses of time to outcome, viremia and laboratory abnormalities comparing MARV/Ang to MARV/MtE-Mus.

Outcome Crude HR (95% CI) Adjusted HR (95% CI)
Death 22.10 (7.08, 68.93) * 25.08 (18.02, 34.91) *
Anorexia 5.42 (2.55, 11.54) * 6.19 (4.94, 7.76) *
Rash 23.79 (6.49, 87.19) * 21.48 (15.04, 30.70) *
Viremia (N = 41; ≥5.12 log copies/mL) 1.70 (0.87, 3.32) 1.51 (0.69, 3.30)
High viremia (N = 41) 4.06 (1.86, 8.86) * 3.75 (1.53, 9.18)
Anemia † (N = 34) 1.20 (0.51, 2.81) 1.51 (0.55, 4.18)
Immune activation
  • 1.

    CRP elevation ‡ (N = 26)

 23.94 (4.31, 133.04) * 22.44 (3.34, 150.87) *
  • 2.

    Leukocytosis ‡ (N = 47)

 8.98 (2.37, 33.95) * 10.48 (2.39, 46.01) *
Organ dysfunction
  • 3.

    ALT elevation ‡ (N = 47)

 3.15 (1.53, 6.48) * 3.41 (1.39, 8.37)
  • 4.

    AST elevation ‡ (N = 47)

 2.62 (1.32, 5.23) * 2.97 (1.27, 6.91)
  • 5.

    Creatinine elevation‡ (N = 47)

 40.50 (5.05, 324.82) * 43.40 (4.93, 382.04) *
Coagulopathy
  • 6.

    PT elevation ‡ (N = 39)

 25.17 (2.86, 221.71) * 20.30 (2.03, 203.02)
  • 7.

    aPTT elevation ‡ (N = 39)

 5.32 (1.91, 14.79) * 5.46 (1.73, 17.21)
  • 8.

    Fibrinogen decrease † (N = 39)

 6.72 (2.35, 19.26) * 7.37 (2.07, 26.28) *
  • 9.

    Thrombocytopenia † (N = 41)

 1.69 (0.72, 3.95) 2.60 (0.95, 7.16)

Note: Hazard ratio adjusted for age, sex, and baseline weight. ALT, alanine transaminase; AST, aspartate transaminase; aPTT, activate partial thromboplastin time; CRP, C-reactive protein; PT, prothrombin time * p-value < 0.0036; † <Lower limit of normal for each sex; ‡ ≥2× Upper limit of normal for each sex.