Fig. 2.

Examples of CISH miR-21 expression patterns in the tumor periphery. a, a′ Case with dominant stromal miR-21 expression where the tumor budding cells are difficult to distinguish from the miR-21 positive stromal cells. Close-up showing a possible tumor budding cell (arrow) among many miR-21-expression stromal cells. b, b′ Case with few miR-21 positive tumor budding cells (arrows) with some miR-21 expression in the surrounding stromal cells. c, c′ Case with dominant epithelial miR-21 expression. miR-21 expression is evident in the tumor budding cells (arrows). IF the invasive front of the colon adenocarcinoma