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. 2018 Sep 3;29(11):843–865. doi: 10.1007/s00335-018-9777-0

Fig. 3.

Fig. 3

Role of the innate and adaptive immune cells following the irradiation of tumour cells. HPC haematopoietic progenitor cells. Bold text and arrows denote the essential pathway of RT-induced immune activation by (i) direct or indirect (ROS-RNS-mediated) DNA damage, (ii) antigen presentation and activation by DCs, and (iii) expansion and specificity of the adaptive immune response. Image modified from (Kamrava et al. 2009) and prepared using Servier Medical Art (https://smart.servier.com/)