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. 2018 Aug 29;374(3):607–617. doi: 10.1007/s00441-018-2905-z

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Non-mitogenic (S117A) FGF2 protects cardiomyocytes from Dox toxicity. (a) The effect of doxorubicin (Dox) on LDH released to the medium by cardiomyocytes, as well as the effect of pretreatment with S117A-FGF2, versus FGF2, on Dox-induced LDH release, as indicated. (b) The effect of Dox on the percentage of dead cells, as measured by the calcein-AM/ethidium homodimer assay; the effect of pretreatment with S117A-FGF2, or FGF2, on Dox-induced cell death is also shown. Representative fluorescence images are included in (c-c′″), where green or red stain live or dead cells, respectively. Brackets mark groups that differ significantly from each other (n = 4), in both (a) and (b)