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. 2018 Aug 29;374(3):607–617. doi: 10.1007/s00441-018-2905-z

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© The Author(s) 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — S117A-FGF2 requires FGFR1 to protect cardiomyocytes against Dox damage. (a) The effect of S117A-FGF2 on relative pY766-FGFR1 after 30-min cardiomyocyte stimulation and after Dox exposure for another 30 min. Brackets show groups significantly different from each other (n = 3). Images of the corresponding western blot probed for anti-pY766-FGFR1, or stained with Ponceau S are also included (a’). (b) The effect of PD173074 (FGFR1 inhibitor) on S117A-FGF2 protection from Dox-induced LDH release. Brackets point to groups that are significantly different from each other. In the presence of PD173074, S117A-FGF2 is unable to reduce Dox-induced LDH release